Communication Affichée: Maladies neuro-musculaires

Le 01/12/2022 de 09:00 à 10:30

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Profil cognitif de patients atteints d’un Syndrome de Guillain-Barré avec plainte attentionnelle interférant avec les activités quotidiennes : une étude de cas multiples

Petra Breuckmann (Boissise-le-roi, France), Emilie Dubourg (Boissise-le-roi, France), Sébastien Gragy (Boissise-le-roi, France), Clarisse Boëssé (Boissise-le-roi, France), Stéphanie Correia (Boissise-le-roi, France), Anne-Gaëlle Grosmaire (Boissise-le-roi, France), Christophe Duret (Boissise-le-roi, France), Ophélie Pila (Boissise-le-roi, France)

Objective : Fatigue and pain are common in patients with Guillain-Barré syndrome (GBS), impacting on Quality of Life (QoL). In contrast, literature doesn’t describe cognitive symptoms while several patients admitted after GBS in our rehabilitation center had attentional complaints interfering with their daily living activities. The objective of the present study was to explore cognitive profile in these patients.

Material / Patients and Methods : All patients with GBS were evaluated (T1) using a set of cognitive tests (mainly attentional and executive functions). Patients were also evaluated (T1) and reevaluated at 10-month interval (T2) using Fatigue Severity Scale (FSS), numerical rating scale for pain, Barthel index (BI) and 36-item short-form health survey (SF-36).

Results : Four patients were studied; mean age of 47 years (range 26-58) and mean time since GBS onset of 18 months (range 5-41). Two patients had attentional complaints but cognitive evaluations reported an efficient and stable cognitive functioning. All patients reported significant fatigue (FSS ≥4) at T1 while three had persistent fatigue at T2. Pain score was ≥5 in three patients at T1 and only in one patient at T2. Only one patient had a low BI score which was stable over time (<60 at T1 and T2). Mean SF-36 scores (mental and physical components) were close to the average score of 50 at T1 and T2 indicating a deterioration in QoL.

Discussion - Conclusion : Despite several patients reported cognitive complaints, cognitive evaluations did not document any cognitive impairments. Fatigue and pain might explain attentional difficulties in daily living in some patients with altered QoL.

Keywords : Guillain-Barré Syndrome, Cognitive, Fatigue